Polynucleotides: the regeneration treatment everyone’s talking about
If you’ve been anywhere near skin TikTok lately, you’ll have heard the word polynucleotides. They’re one of the most talked-about treatments in aesthetics right now — and unlike a lot of trends, this one is genuinely earning its place.
So what actually are they?
Polynucleotides are purified fragments of DNA (most commonly derived from salmon or trout) that act as a signal to your own cells. Rather than adding volume like a dermal filler, they work deeper — encouraging your skin to repair, hydrate and rebuild from within. Think of them less as a “fill” and more as a conditioning treatment for the skin itself.
What do they do for the skin?
The results are about quality rather than change: improved hydration, better elasticity, a smoother texture and a healthier, more resilient look. They’re especially well suited to delicate areas — under the eyes, the neck, and skin that looks tired, thin or crepey.
This is regeneration, not augmentation. You still look entirely like you — just like you on a very good day.
Who are they for?
Polynucleotides suit almost everyone, but they’re a particularly good fit if your concern is tired, dull or ageing skin rather than volume loss. They also pair beautifully with our wider approach — treating skin as a whole rather than chasing one fix.
How we use them at DermaGlo
We never treat in isolation. Polynucleotides slot into a considered plan alongside the right homecare and in-clinic support — which is exactly the thinking behind The DermaGlo Method. If you’re curious whether they’re right for you, the honest answer comes from a consultation and a proper look at your skin.
Want this looked at properly?
Every plan starts with a relaxed consultation and an honest look at your skin.